How it Works

In the body, water penetrates the hydrophobic matrix, which can be an implant or a small particle in suspension, for example, in a topical cream.  This causes a slow dissolution of the codrug particle, which is the rate limiting step for sustained release.  Once in solution, a conformational change occurs in the codrug molecule, allowing base hydrolysis to occur. This leads to a “re-formation” of the parent drugs.