Olanzapine Plexis formulation release data

Olanzapine particles were coated with successive laminations of biocompatible polymers. The final formulation (filled triangles) consists of a “sandwich” of polymers. The apparent half life of dissolution is ca. 10 days.

In vitro release of olanzapine formulations

These “sandwich” coated particles (6mg) were injected subcutaneously into Sprague-Dawley rats (n=6). Serum samples (open circles) were taken at times indicated and HPLC performed. 

For reference, data from Aravigiri et al showing PK after oral dosing in rats (closed circles) is shown.

In vivo release of olanzapine formulations